Typical vial
50 mg
Common dose
10 mg
Frequency
7×/week
Half-life
—
Calculate Epithalon / Epitalon reconstitution
Open the free calculator pre-filled with Epithalon / Epitalon values — no account needed.
Dosing & Protocol Overview
Research Notes
Research protocols vary in duration and yearly frequency.
How Reconstitution Works
Reconstitution is the process of mixing a lyophilized (freeze-dried) peptide powder with bacteriostatic water to create an injectable solution. The concentration depends on how much BAC water you add to the vial.
For a 50 mg vial of Epithalon / Epitalon, the calculator works out the mg/ml concentration based on your BAC water volume, then converts your target dose (10 mg) into the exact number of units to draw on an insulin syringe.
Try it now — pre-filled for Epithalon / EpitalonTrack Your Epithalon / Epitalon Protocol
Once you've calculated your reconstitution, ReconDose lets you log every injection, build a dosing schedule, track side effects, and record biomarkers — all in one place. Create a free account to get started.
Research & References
The following publicly available studies are provided for research and educational purposes only. They are not medical advice. Click through to read the original publications.
Khavinson VKh, Bondarev IE, Butyugov AA · Bulletin of Experimental Biology and Medicine · 2003
English-language publication. Epithalon (Ala-Glu-Asp-Gly) induced expression of telomerase catalytic subunit, enzymatic telomerase activity, and telomere elongation in telomerase-negative human fetal fibroblasts. Suggests reactivation of telomerase gene in somatic cells, indicating potential for prolonging cell population lifespan.
Khavinson VKh · Neuro Endocrinology Letters · 2002
144-page supplement reviewing Khavinson's work on peptide bioregulators. Epithalamin increases melatonin production, improves immune parameters, produces anticarcinogenic effects, stimulates antioxidant defenses, and restores reproductive function in old rats. Increases lifespan in rats, mice, and fruit flies. Describes design principles for short tissue-specific peptides including Epitalon (Ala-Glu-Asp-Gly).
Khavinson VKh, Morozov VG · Advances in Gerontology · 2002
6-8 year clinical study in 266 elderly patients. Thymalin and Epithalamin normalized cardiovascular, endocrine, immune, and nervous system function. 2.0-2.4-fold decrease in acute respiratory disease incidence. Mortality decreased 2.0-2.1x with Thymalin, 1.6-1.8x with Epithalamin, and 4.1x with combined annual treatment over 6 years vs control.
Khavinson VKh, Izmaylov DM · Mechanisms of Ageing and Development · 2000
English-language publication. Epitalon increased lifespan of Drosophila melanogaster by 11-16% at concentrations of 0.001 and 0.0001%. Demonstrated antioxidant effects. Established epitalon as a geroprotector (anti-aging compound) in a well-controlled invertebrate model.
Khavinson VKh, Kuznik BI, Ryzhak GA · Advances in Gerontology · 2014· CC-BY-NC
English-language review of clinical efficacy of peptide bioregulators (Timalin, Thymogen, Vilon, Epithalamin, Prostatilen, Cortexin, Retinalamin). Analyzes their use as geroprotectors across all age groups. Reviews long-term clinical studies demonstrating disease prevention and health maintenance in elderly populations.
Have a study we should add? Let us know. See our research hub for more studies and the Khavinson peptide bioregulator collection.