Typical vial
5 mg
Common dose
2 mg
Frequency
2×/week
Half-life
—
Calculate TB-500 reconstitution
Open the free calculator pre-filled with TB-500 values — no account needed.
Dosing & Protocol Overview
Research Notes
Research protocols vary widely in weekly totals and cycling.
How Reconstitution Works
Reconstitution is the process of mixing a lyophilized (freeze-dried) peptide powder with bacteriostatic water to create an injectable solution. The concentration depends on how much BAC water you add to the vial.
For a 5 mg vial of TB-500, the calculator works out the mg/ml concentration based on your BAC water volume, then converts your target dose (2 mg) into the exact number of units to draw on an insulin syringe.
Try it now — pre-filled for TB-500Track Your TB-500 Protocol
Once you've calculated your reconstitution, ReconDose lets you log every injection, build a dosing schedule, track side effects, and record biomarkers — all in one place. Create a free account to get started.
Research & References
The following publicly available studies are provided for research and educational purposes only. They are not medical advice. Click through to read the original publications.
Goldstein AL, et al. · Europe PMC (Preprint) · 2026· CC-BY
Scoping review of 80 studies from 1,772 records. Evidence was weighted toward in vitro and animal designs. Most studies evaluated TB4 rather than TB-500. Human evidence concentrated in ocular/corneal and wound/skin settings. Direct TB-500 evidence was limited to a single study. Literature supports repair pathways but remains largely preclinical.
Goldstein AL, et al. · Expert Opinion on Biological Therapy · 2015
Review of Tβ4's regenerative activity including stem cell maturation, tissue repair, eye injuries, dermal wounds, cardiac repair post-MI, and brain healing post-stroke. Discusses potential clinical applications in kidney, liver, spinal cord, bone, and ligament repair.
Kim H, et al. · PubMed · 2024· CC-BY
Pharmacokinetic study identifying TB-500 metabolites. Ac-LK was the primary metabolite; Ac-LKK was a long-term metabolite detected up to 72 hours. No cytotoxicity found. Ac-LKKTE showed significant wound healing activity in fibroblasts. Suggests TB-500's wound-healing activity may be mediated through its metabolites.
Sosne G, et al. · Annals of the New York Academy of Sciences · 2010
Compassionate use study in 9 patients (ages 37-84) with chronic neurotrophic corneal defects treated with Tβ4 eye drops for 28-49 days. Six patients with geographic defects showed dramatic healing without neovascularization. All patients reported reduced ocular irritation.
Have a study we should add? Let us know. See our research hub for more studies and the Khavinson peptide bioregulator collection.